Opportunity Information: Apply for RFA DA 25 062
The HEAL Initiative: JCOIN Phase II Innovation Hubs (R01 Clinical Trial Optional) funding opportunity (RFA-DA-25-062) is an NIH grant that supports research aimed at reducing opioid-related harm among people who are involved with the U.S. criminal-legal system. The core problem it targets is well documented: people entering jails and prisons have disproportionately high rates of substance use disorder (SUD) and opioid use disorder (OUD), many experience acute opioid withdrawal soon after incarceration, and their overdose risk rises sharply after release, especially when they were not offered medications for opioid use disorder (MOUD) during detention. Despite strong evidence for MOUD, many U.S. jails still do not provide these medications broadly to everyone who could benefit, creating a major gap between what works clinically and what is routinely delivered in justice settings.
This program sits within the Justice Community Opioid Innovation Network (JCOIN) and emphasizes translation of research into practice in real-world criminal-legal environments. In practical terms, the funded work is meant to help justice systems and their community partners increase access to and delivery of evidence-based OUD treatment, particularly MOUD, by tackling on-the-ground barriers that prevent implementation. JCOIN-supported projects typically use hybrid effectiveness-implementation trial approaches, meaning they evaluate both clinical outcomes (for example, MOUD uptake, retention, overdose events, relapse, continuity of care) and implementation outcomes (for example, feasibility, fidelity, acceptability, sustainability, workflow integration, staffing and training needs, reimbursement and policy barriers). The opportunity highlights that JCOIN is the only HEAL Initiative effort with a primary focus on justice-involved populations and criminal-legal systems, underscoring its specialized mission and setting.
The award mechanism is an R01 (Clinical Trial Optional), which signals flexibility: applicants may propose studies that include a clinical trial component, but they are not required to. The activity category is listed under Education and Health, and the CFDA number is 93.279. The opportunity is administered by the National Institutes of Health, created on June 6, 2024, with an original closing date of January 22, 2025. The listed award ceiling is $2,250,000, indicating the maximum amount expected per award under this announcement.
Eligibility is broad and intentionally spans the types of organizations that can influence or partner with justice settings. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other organizations. The announcement also explicitly calls out additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
At the same time, the opportunity places clear limits on foreign participation. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed as defined in the NIH Grants Policy Statement, which generally means a U.S.-based applicant can include certain specific foreign elements or collaborations if they meet NIH policy definitions and justification requirements, even though the applicant organization itself must be domestic.
Overall, this grant opportunity is geared toward building and advancing “innovation hubs” in Phase II of JCOIN, where teams can test and scale practical strategies that make MOUD access more routine in jails, prisons, courts, probation/parole contexts, and the community reentry continuum. The central expectation is that funded projects will generate actionable evidence about what it takes to implement and sustain evidence-based OUD treatment for justice-involved people, with the broader HEAL goal of reducing overdose deaths and closing treatment gaps in one of the highest-risk populations in the country.Apply for RFA DA 25 062
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "HEAL Initiative: JCOIN Phase II Innovation Hubs (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2024-06-06.
- Applicants must submit their applications by 2025-01-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,250,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the funding opportunity called?
The opportunity is titled The HEAL Initiative: JCOIN Phase II Innovation Hubs (R01 Clinical Trial Optional) and is identified as RFA-DA-25-062.
Which federal agency is administering this grant?
This is an NIH (National Institutes of Health) grant opportunity administered by the National Institutes of Health.
What program or network is this opportunity part of?
This opportunity sits within the Justice Community Opioid Innovation Network (JCOIN) and is part of the broader HEAL (Helping to End Addiction Long-term) Initiative.
What problem is the program trying to address?
The program targets opioid-related harm among people involved with the U.S. criminal-legal system. It is based on well-documented risks in justice settings, including high rates of substance use disorder (SUD) and opioid use disorder (OUD), acute opioid withdrawal soon after incarceration, and a sharply increased overdose risk after release, especially when people are not offered medications for opioid use disorder (MOUD) while detained.
What is the main focus of the proposed research?
The focus is on translating evidence into practice in real-world criminal-legal environments by helping justice systems and community partners increase access to and delivery of evidence-based OUD treatment, particularly MOUD, by addressing practical barriers that interfere with implementation.
What types of settings does this opportunity aim to impact?
The opportunity is geared toward strategies that make MOUD access more routine across criminal-legal and reentry contexts, including jails, prisons, courts, probation/parole, and the community reentry continuum.
What is meant by “Innovation Hubs” in JCOIN Phase II?
Based on the description provided, “Innovation Hubs” are teams or collaborative efforts intended to test and scale practical strategies that improve implementation and sustainability of evidence-based OUD treatment (especially MOUD) within justice-involved contexts.
What is the award mechanism for this announcement?
The award mechanism is an R01, and the opportunity is listed as Clinical Trial Optional.
Does an application have to include a clinical trial?
No. “Clinical Trial Optional” indicates applicants may propose studies that include a clinical trial component, but a clinical trial is not required.
What kinds of study designs are typical for JCOIN-supported projects?
JCOIN-supported projects typically use hybrid effectiveness-implementation trial approaches, meaning they evaluate both clinical outcomes and implementation outcomes in real-world criminal-legal settings.
What clinical outcomes are mentioned as examples in the opportunity description?
Examples of clinical outcomes include MOUD uptake, retention, overdose events, relapse, and continuity of care.
What implementation outcomes are mentioned as examples in the opportunity description?
Examples of implementation outcomes include feasibility, fidelity, acceptability, sustainability, workflow integration, staffing and training needs, and reimbursement and policy barriers.
Why does this opportunity emphasize MOUD in justice settings?
The description highlights a major gap between evidence and routine practice: despite strong evidence for MOUD, many U.S. jails do not provide these medications broadly to everyone who could benefit. The program aims to reduce that gap by identifying and overcoming on-the-ground barriers to implementation.
How is JCOIN positioned within the HEAL Initiative?
The opportunity notes that JCOIN is the only HEAL Initiative effort with a primary focus on justice-involved populations and criminal-legal systems, emphasizing its specialized mission and setting.
What is the CFDA number listed for this opportunity?
The CFDA number is 93.279.
What activity category is associated with this funding opportunity?
The activity category is listed under Education and Health.
When was this opportunity created?
The opportunity was created on June 6, 2024.
What was the original closing date?
The original closing date listed is January 22, 2025.
What is the award ceiling for this announcement?
The listed award ceiling is $2,250,000, indicating the maximum amount expected per award under this announcement.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organization types, such as:
- State, county, city/township, and special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Tribal organizations other than federally recognized tribal governments
- Public housing authorities and Indian housing authorities
- Nonprofits with or without 501(c)(3) status (excluding institutions of higher education within those nonprofit categories)
- For-profit organizations other than small businesses
- Small businesses
- Other organizations
Are there additional eligible applicant types specifically called out?
Yes. The announcement explicitly calls out additional eligible applicant types, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply.
Can a U.S. organization apply if it has a non-U.S. component?
Non-domestic components of U.S. organizations are not eligible to apply as components under this opportunity, based on the information provided.
Are any foreign collaborations allowed at all?
Yes. The opportunity states that foreign components are allowed as defined in the NIH Grants Policy Statement. In practical terms, the applicant organization must be domestic, but certain foreign elements or collaborations may be included if they meet NIH policy definitions and justification requirements.
What is the central expectation for funded projects?
The central expectation is that projects will produce actionable evidence about what it takes to implement and sustain evidence-based OUD treatment (particularly MOUD) for justice-involved people, with the broader HEAL goal of reducing overdose deaths and closing treatment gaps in a high-risk population.
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