Opportunity Information: Apply for PAR 17 054
The NIH funding opportunity "Leveraging Existing Cohort Studies to Clarify Risk and Protective Factors for Alzheimers Disease and Related Dementias (R01)" (Funding Opportunity Number: PAR-17-054) is a discretionary health research grant designed to strengthen what researchers can learn about Alzheimers disease and related dementias (often abbreviated AD/ADRD) by intentionally combining data from multiple existing cohort studies. The central idea is that single cohorts, even well-run ones, can be limited by sample size, population makeup, follow-up time, and the relatively low number of dementia outcomes in certain subgroups. By bringing cohorts together, applicants are expected to increase statistical power, enable more precise estimates, and improve the ability to detect and validate risk factors and protective factors across different populations and settings.
A defining feature of this FOA is its emphasis on leveraging already-established cohort resources rather than building new cohorts from scratch. In practical terms, the work supported under this announcement would typically involve pooling data, harmonizing measures across studies, coordinating analyses, and conducting rigorous cross-cohort comparisons. This approach can be especially valuable for addressing questions that require large numbers of participants or outcomes, such as identifying subtle effects of exposures over time, examining interactions among genetic, environmental, behavioral, and social factors, or evaluating whether certain factors operate differently by age, sex, race and ethnicity, geography, or other characteristics. The goal is not simply to create a larger dataset, but to use the combined evidence to clarify which factors truly increase risk, which appear protective, and how those relationships may vary across groups.
The funding mechanism is an R01 research project grant, which generally supports hypothesis-driven, investigator-initiated research projects with clearly defined aims. The activity category is Health, and the CFDA number listed for this opportunity is 93.866. The sponsoring agency is the National Institutes of Health. The listing provided does not specify an award ceiling or the number of expected awards, which suggests those details were either not set in the summary data or were handled through NIH institute-specific budgeting and program priorities at the time. The original closing date shown is May 7, 2020, and the opportunity creation date is November 16, 2016, indicating this was a standing program announcement that was active over multiple years rather than a one-time solicitation.
Eligibility is broad and includes a wide range of public, private, nonprofit, and governmental entities. Standard eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; federally recognized and other-than-federally recognized Native American tribal organizations; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations (other than small businesses) as well as small businesses; and an "Others" category that captures additional eligible types. The FOA also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; non-domestic (non-U.S.) entities/foreign organizations; regional organizations; Indian/Native American tribal governments that are not federally recognized; and U.S. territories or possessions. Taken together, this eligibility language signals an intent to support diverse institutional partners and to encourage research that can draw on varied populations and contexts, including underserved groups and international settings when appropriate.
Overall, the opportunity is aimed at accelerating AD/ADRD discovery by making better use of data that already exist, especially where coordination across cohorts can answer questions that no single study can address confidently on its own. The expected outcomes of funded projects are stronger, more generalizable evidence about dementia-related risk and resilience, improved clarity around potentially modifiable factors, and a more robust empirical foundation for prevention strategies, clinical guidance, and future trials focused on delaying onset, reducing incidence, or mitigating progression of Alzheimers disease and related dementias.Apply for PAR 17 054
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Leveraging Existing Cohort Studies to Clarify Risk and Protective Factors for Alzheimers Disease and Related Dementias (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2016-11-16.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
What is the funding opportunity titled and what is its funding opportunity number?
The opportunity is titled "Leveraging Existing Cohort Studies to Clarify Risk and Protective Factors for Alzheimers Disease and Related Dementias (R01)" and the Funding Opportunity Number is PAR-17-054.
Which federal agency sponsors this grant opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of grant mechanism is used?
This opportunity uses the R01 research project grant mechanism, which generally supports hypothesis-driven, investigator-initiated research projects with clearly defined aims.
What is the overall purpose of this FOA?
The purpose is to strengthen what researchers can learn about Alzheimers disease and related dementias (AD/ADRD) by intentionally combining data from multiple existing cohort studies, enabling stronger and more generalizable evidence about risk factors and protective factors.
What does AD/ADRD mean in this context?
AD/ADRD refers to Alzheimers disease and related dementias.
Why focus on combining data from multiple cohort studies instead of relying on a single cohort?
Single cohorts can be limited by sample size, population makeup, follow-up time, and relatively low numbers of dementia outcomes in certain subgroups. Combining cohorts is intended to increase statistical power, improve precision of estimates, and strengthen the ability to detect and validate risk and protective factors across different populations and settings.
Is this FOA intended to support creation of new cohort studies?
No. A defining feature of this funding opportunity is leveraging already-established cohort resources rather than building new cohorts from scratch.
What kinds of activities are typically supported under this announcement?
Typical activities include pooling data, harmonizing measures across studies, coordinating analyses, and conducting rigorous cross-cohort comparisons.
What is meant by "harmonizing measures" across cohorts?
Within this FOA's framing, harmonizing measures means aligning or standardizing variables and measures across different cohort studies so results can be compared or combined more reliably when conducting pooled or cross-cohort analyses.
What are the expected advantages of pooling cohort data?
Pooling cohorts is expected to increase statistical power, enable more precise estimates, and improve the ability to detect, validate, and compare risk and protective factors across diverse groups and settings.
What kinds of scientific questions is this combined-cohort approach especially useful for?
It is especially useful for questions that require large numbers of participants or outcomes, including identifying subtle effects of exposures over time, examining interactions among genetic, environmental, behavioral, and social factors, and evaluating whether factors operate differently across characteristics such as age, sex, race and ethnicity, and geography.
Is the goal simply to create a larger dataset?
No. The goal is to use combined evidence to clarify which factors truly increase risk, which appear protective, and how those relationships may vary across groups.
What is the activity category for this opportunity?
The activity category is Health.
What CFDA number is associated with this opportunity?
The CFDA number listed is 93.866.
When was this opportunity created?
The opportunity creation date is November 16, 2016.
What is the closing date shown in the listing?
The original closing date shown is May 7, 2020.
Does the listing indicate this was a one-time solicitation or a program announcement active over time?
Based on the creation date (2016) and the closing date shown (2020), the listing indicates it was a standing program announcement active over multiple years rather than a one-time solicitation.
Does the summary information provide an award ceiling?
No. The listing does not specify an award ceiling.
Does the summary information state the number of expected awards?
No. The listing does not specify the number of expected awards.
What does it suggest if award ceiling and number of expected awards are not listed?
It suggests those details were either not set in the summary data or were handled through NIH institute-specific budgeting and program priorities at the time.
Who is eligible to apply?
Eligibility is broad and includes many public, private, nonprofit, and governmental entities, including institutions of higher education, governments at multiple levels, tribal governments and organizations, nonprofits (with and without 501(c)(3) status), for-profit organizations, small businesses, and other eligible entity types described in the FOA.
Are state and local governments eligible applicants?
Yes. Eligible applicants include state governments and local governments such as county, city, or township governments, as well as special district governments.
Are public and private institutions of higher education eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are tribal governments and tribal organizations eligible?
Yes. Eligibility includes federally recognized Native American tribal governments, other-than-federally recognized tribal organizations, and tribal governments that are not federally recognized, as described in the FOA.
Are nonprofits eligible, and does 501(c)(3) status matter?
Yes. The eligibility language includes nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories).
Are for-profit organizations eligible?
Yes. The FOA includes for-profit organizations (other than small businesses) and also explicitly includes small businesses.
Are non-U.S. organizations eligible to apply?
Yes. The FOA highlights that non-domestic (non-U.S.) entities/foreign organizations are included among eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed among eligible applicants.
Does the FOA encourage participation by specific types of institutions or community-based organizations?
Yes. The FOA highlights additional eligible applicants including HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, TCCUs, faith-based or community-based organizations, regional organizations, and eligible federal agencies, among others.
What kinds of populations or settings can benefit from the cross-cohort approach described here?
The approach is intended to help evaluate whether risk and protective factors differ across populations and settings, including differences by age, sex, race and ethnicity, geography, and other characteristics, and to support work drawing on varied populations and contexts, including underserved groups and international settings when appropriate.
What outcomes or impact is this FOA aiming to produce?
Funded projects are expected to produce stronger, more generalizable evidence about dementia-related risk and resilience, improved clarity around potentially modifiable factors, and a more robust empirical foundation for prevention strategies, clinical guidance, and future trials aimed at delaying onset, reducing incidence, or mitigating progression of AD/ADRD.
Browse more opportunities from the same category: Health
Next opportunity: Enhancing Cancer Registries for Early Pediatric and Young Adult Cancer Cases
Previous opportunity: Focused Technology Research and Development (R01)
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 17 054
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 17 054) also looked into and applied for these:
| Funding Opportunity |
|---|
| Enhancing the Target and Biomarker Discovery Efforts of the AMP-AD and M2OVE-AD Consortia (R01) Apply for RFA AG 17 054 Funding Number: RFA AG 17 054 Agency: National Institutes of Health Category: Health Funding Amount: $750,000 |
| Global Infectious Disease Research Training Program (D43) Apply for PAR 17 057 Funding Number: PAR 17 057 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Investigator Initiated Extended Clinical Trial (R01) Apply for PAR 17 056 Funding Number: PAR 17 056 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Planning Grant for Global Infectious Disease Research Training Program (D71) Apply for PAR 17 058 Funding Number: PAR 17 058 Agency: National Institutes of Health Category: Health Funding Amount: $46,000 |
| Pragmatic Trials for Dementia Care in Long-term Services and Support (LTSS) Settings (R01) Apply for RFA AG 17 064 Funding Number: RFA AG 17 064 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Pragmatic Trials for Dementia Care in Long-term Services and Support (LTSS) Settings (R21/R33) Apply for RFA AG 17 065 Funding Number: RFA AG 17 065 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Alzheimer's Disease Outcomes Research Resource (U2C) Apply for RFA AG 17 052 Funding Number: RFA AG 17 052 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Enhancing Cancer Registries for Early Pediatric and Young Adult Cancer Cases Apply for CDC RFA DP14 140204CONT17 Funding Number: CDC RFA DP14 140204CONT17 Agency: Centers for Disease Control - NCCDPHP Category: Health Funding Amount: Case Dependent |
| Limited Competition: Clinical Trials in Organ Transplantation in Children (CTOT-C): Mechanistic Ancillary Studies (U01) Apply for RFA AI 16 078 Funding Number: RFA AI 16 078 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
| Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01) Apply for PAR 17 063 Funding Number: PAR 17 063 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Leveraging Existing Resources for Research on Lewy Body Dementia (R03) Apply for RFA NS 17 016 Funding Number: RFA NS 17 016 Agency: National Institutes of Health Category: Health Funding Amount: $50,000 |
| Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R41/R42) Apply for PAS 17 065 Funding Number: PAS 17 065 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44) Apply for PAS 17 064 Funding Number: PAS 17 064 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Tools for Clinical Care and Management of Alzheimers Disease (AD) and Its Comorbidities (R41/R42) Apply for PAR 17 066 Funding Number: PAR 17 066 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Tools for Clinical Care and Management of Alzheimers Disease (AD) and its Comorbidities (R43/R44) Apply for PAR 17 067 Funding Number: PAR 17 067 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Pilot Clinical Trials Targeting HIV-1 Reservoirs in Children (U01) Apply for RFA AI 16 086 Funding Number: RFA AI 16 086 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Maximizing Access to Research Careers Undergraduate - Student Training in Academic Research (MARC U-STAR) (T34) Apply for PAR 17 068 Funding Number: PAR 17 068 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| HIV and AIDS Community Grants Program Apply for COMMGRANTSHIVAIDS17 Funding Number: COMMGRANTSHIVAIDS17 Agency: U.S. Mission to South Africa Category: Health Funding Amount: $50,000 |
| Institutional Training Programs to Advance Translational Research on Alzheimers Disease and AD Related Dementias (T32) Apply for RFA AG 17 063 Funding Number: RFA AG 17 063 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Innovative Programs to Enhance Research Training (IPERT) (R25) Apply for PAR 17 070 Funding Number: PAR 17 070 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 17 054", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.