Opportunity Information: Apply for RFA NS 23 010
The NIH StrokeNet - Regional Coordinating Stroke Centers (RCC) opportunity for 2023 (RFA-NS-23-010) is a National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH) funding announcement that supports the NIH StrokeNet clinical trials network through a U24 cooperative agreement mechanism. The overarching aim is to strengthen and expand a national infrastructure of high-performing stroke research sites that can efficiently run rigorous, multi-site clinical studies addressing stroke prevention, acute treatment, and recovery. StrokeNet was originally established in 2013 to bring coordination, standardization, and speed to stroke clinical research, while still maintaining a balanced research portfolio across prevention, treatment, and recovery rather than concentrating on only one part of the stroke care continuum.
Under this FOA, funded RCCs serve as regional academic medical center hubs that coordinate and support a group of affiliated partners, performance sites, or satellite stroke centers. The expectation is that these regional groupings are ready and committed to enrolling and randomizing patients into NINDS-funded StrokeNet studies. In practical terms, an RCC is meant to be more than a single hospital with research capability; it is a coordinated regional engine for trial execution, patient recruitment, and consistent protocol adherence across multiple linked sites. The network structure separates responsibilities so that national-level trial coordination and data operations are handled by the National Coordinating Center (NCC) and the National Data Management Center (NDMC), while the RCCs focus on regional trial implementation, site performance, and recruitment into StrokeNet studies.
The opportunity emphasizes that RCCs must demonstrate both clinical excellence and research readiness in stroke. That includes specialized expertise in stroke management, a strong record in stroke research, and proven ability to recruit stroke patients into studies. The FOA also stresses multidisciplinary collaboration as a core requirement. Each RCC is expected to show strong working relationships spanning vascular neurology, emergency medicine, interventional neuroradiology, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and pediatric neurology. The point of this broad integration is to ensure that eligible patients are identified across the full clinical pathway and offered participation in StrokeNet trials whenever appropriate, rather than limiting recruitment to a narrow service line or single department.
Although the StrokeNet network coordinates major clinical research efforts, this specific FOA is labeled "Clinical Trials Not Allowed." That generally indicates the RCC award itself is intended to fund the infrastructure, coordination, and operational capacity needed to participate in StrokeNet trials, rather than proposing and running an independent clinical trial directly under this grant. StrokeNet’s multi-site exploratory and confirmatory Phase 3 trials, along with biomarker-validation studies that are immediately preparatory to trials and ancillary studies that add scientific aims to active studies, are coordinated through the network’s dedicated national centers (NCC and NDMC) rather than being initiated as standalone trials by RCC applicants through this mechanism.
A notable additional feature is that the NIH Stroke Trials Network includes an active stroke research career advancement program. This signals that StrokeNet is not only focused on delivering trials efficiently right now, but also on building the next generation of stroke investigators and research leadership, using the network environment as a training and professional development platform.
In terms of eligibility, the FOA is broad and includes many U.S.-based public and private entities. Eligible applicants include state, county, and city governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other categories specified by NIH. The FOA also explicitly highlights eligibility interest in a range of institution types and community-connected organizations, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, it clearly restricts foreign involvement: non-U.S. entities and foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.
Key administrative details in the posted source information include the funding instrument (cooperative agreement), the activity category (health), and the associated CFDA number 93.853. The original application closing date listed is February 28, 2023. The award ceiling shown in the source data is $1,750,000, indicating the maximum award amount anticipated per award under this announcement, subject to NIH funding decisions and the final approved scope and budget.
Overall, this 2023 RCC FOA is essentially about maintaining and expanding the operational backbone of NIH StrokeNet by funding regional hubs that can reliably recruit patients, coordinate multiple linked sites, and execute complex, multi-site stroke studies in close collaboration with national coordinating and data centers. The intended outcome is a more efficient, higher-quality national clinical trials system that can test promising stroke interventions faster and more consistently across diverse clinical settings, while also developing future leaders in stroke clinical research.Apply for RFA NS 23 010
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIH StrokeNet- Regional Coordinating Stroke Centers for year 2023 (U24 - Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853.
- This funding opportunity was created on 2022-12-15.
- Applicants must submit their applications by 2023-02-28. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,750,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Funding Opportunity |
|---|
| NIH StrokeNet National Coordinating Center for year 2023 (U01 Clinical Trials Not Allowed) Apply for RFA NS 23 009 Funding Number: RFA NS 23 009 Agency: National Institutes of Health Category: Health Funding Amount: $1,750,000 |
| NIH StrokeNet National Data Management Center for year 2023 (U01 Clinical Trials Not Allowed) Apply for RFA NS 23 008 Funding Number: RFA NS 23 008 Agency: National Institutes of Health Category: Health Funding Amount: $1,000,000 |
| Research Networks to Promote Multidisciplinary Mechanistic Studies on Music-Based Interventions for Pain or Alzheimers Disease and Alzheimers Disease Related Dementias (AD/ADRD) (U24 Clinical Trial Optional) Apply for RFA AT 23 009 Funding Number: RFA AT 23 009 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| Limited Competition: Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) (P20 - Clinical Trial Optional) Apply for PAR 23 063 Funding Number: PAR 23 063 Agency: National Institutes of Health Category: Health Funding Amount: $1,500,000 |
| Biomedical Research Facilities (C06 Clinical Trial Not Allowed) Apply for PAR 23 045 Funding Number: PAR 23 045 Agency: National Institutes of Health Category: Health Funding Amount: $8,000,000 |
| Autoimmunity Centers of Excellence, Basic Research Program (U19 Clinical Trial Not Allowed) Apply for RFA AI 22 070 Funding Number: RFA AI 22 070 Agency: National Institutes of Health Category: Health Funding Amount: $150,000 |
| Autoimmunity Centers of Excellence, Clinical Research Program (UM1 Clinical Trial Required) Apply for RFA AI 22 071 Funding Number: RFA AI 22 071 Agency: National Institutes of Health Category: Health Funding Amount: $150,000 |
| AHRQ and PCORI Learning Health System Embedded Scientist Training and Research Centers (P30) Apply for RFA HS 23 001 Funding Number: RFA HS 23 001 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: Case Dependent |
| Pilot Studies for the Spectrum of Alzheimers Disease/Alzheimers Disease-Related Dementias and Age-Related Cognitive Decline (R61 Clinical Trial Optional) Apply for PAR 23 083 Funding Number: PAR 23 083 Agency: National Institutes of Health Category: Health Funding Amount: $325,000 |
| Early and Late Stage Clinical Trials for the Spectrum of Alzheimers Disease/Alzheimers Related Dementias and Age-Related Cognitive Decline (R01 Clinical Trial Optional) Apply for PAR 23 081 Funding Number: PAR 23 081 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Understanding the Supply of Professional Dementia Care Providers and Their Decisions (U54 Clinical Trial Not Allowed) Apply for RFA AG 24 024 Funding Number: RFA AG 24 024 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Limited Competition: Brain Tissue Resource Center for Alcohol Research (R28 Clinical Trial Not Allowed) Apply for PAR 23 068 Funding Number: PAR 23 068 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIAMS Resource-based Centers for Bone, Muscle and Orthopaedic Research (P30 - Clinical Trial Not Allowed) Apply for RFA AR 24 002 Funding Number: RFA AR 24 002 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| NIAMS Skin Biology and Diseases Resource-based Centers (P30 - Clinical Trial Not Allowed) Apply for RFA AR 24 001 Funding Number: RFA AR 24 001 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| Bidirectional Influences Between Adolescent Social Media Use and Mental Health (R01 Clinical Trial Optional) Apply for RFA MH 23 115 Funding Number: RFA MH 23 115 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Bidirectional Influences Between Adolescent Social Media Use and Mental Health (R21 Clinical Trial Optional) Apply for RFA MH 23 116 Funding Number: RFA MH 23 116 Agency: National Institutes of Health Category: Health Funding Amount: $275,000 |
| HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed) Apply for PAR 23 069 Funding Number: PAR 23 069 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
| Research Centers in Minority Institutions (RCMI) (U54 Clinical Trial Optional) Apply for RFA MD 23 001 Funding Number: RFA MD 23 001 Agency: National Institutes of Health Category: Health Funding Amount: $3,500,000 |
| Laboratories to Optimize Digital Health (R01 Clinical Trial Required) Apply for PAR 23 096 Funding Number: PAR 23 096 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Tools and resources to understand the vascular pathophysiology of in vivo neuroimaging findings in TBI-related dementia and/or VCID (U24 - Clinical Trials Not Allowed) Apply for RFA NS 23 002 Funding Number: RFA NS 23 002 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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