Cancer Prevention Clinical Trials Network (CP-CTNet): CP-CTNet Sites (UG1 Clinical Trial Required) | RFA CA 24 024

Opportunity Information: Apply for RFA CA 24 024

The National Cancer Institute (NCI), through its Division of Cancer Prevention (DCP), is soliciting applications for performance sites within the Cancer Prevention Clinical Trials Network (CP-CTNet) under the UG1 cooperative agreement mechanism, with a clinical trial required. The purpose of this opportunity is to support the real-world infrastructure and operational capacity needed to plan and conduct early-phase (phase 0 through phase 2) cancer prevention clinical trials. In practical terms, CP-CTNet is positioned as DCP's primary national platform for moving promising cancer preventive interventions from early clinical testing toward broader development, by running trials that focus on biological activity and credible intermediate signals rather than large, definitive endpoint trials.

The trials conducted through CP-CTNet are designed to evaluate the biologic effects of preventive interventions and to identify clinically meaningful correlates that can indicate whether an intervention is on a plausible path to preventing cancer. These studies often emphasize mechanistic outcomes, biomarker modulation, pharmacodynamic effects, dosing and feasibility questions, and other early indicators that help determine whether an intervention should advance. The network is expected to develop and run multiple prevention trials across different organ sites, reflecting the reality that cancer risk and prevention strategies vary by tissue type, exposure, and underlying biology. The program also explicitly anticipates collaborative studies across the network, meaning sites are not just running isolated trials but are participating in a coordinated set of prevention research activities.

This specific NOFO is aimed at the CP-CTNet "sites" that will do the hands-on work of planning and performing the clinical trials. Because it is a cooperative agreement (UG1), the relationship between the awardees and NCI is intended to be more collaborative than a typical grant, with substantial federal scientific and/or programmatic involvement expected during the planning and conduct of the trials. The emphasis is on building and sustaining the clinical research capability to execute prevention trials efficiently and consistently within a national network structure.

Eligibility is broad and includes many common public, academic, nonprofit, and private-sector applicant types, such as state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations other than small businesses; and small businesses. The announcement also highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, it clearly states that non-domestic (non-U.S.) entities are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply; however, foreign components are allowed as defined in the NIH Grants Policy Statement, which typically means specific, well-justified elements of the work may be carried out by foreign collaborators under NIH rules even though the applicant organization must be domestic.

Key administrative details include the funding opportunity title "Cancer Prevention Clinical Trials Network (CP-CTNet): CP-CTNet Sites (UG1 Clinical Trial Required)," funding opportunity number RFA-CA-24-024, and agency name National Institutes of Health (NIH) with NCI as the sponsoring institute. The opportunity is categorized as discretionary and uses the cooperative agreement funding instrument. The activity category is listed under education and health, and the CFDA numbers associated with this program are 93.393 and 93.399. The original closing date is 2024-10-31, and the opportunity was created on 2024-08-12. The provided source information does not specify an award ceiling or the expected number of awards, indicating applicants should consult the full NOFO text for budget limits, project period details, and the anticipated scale of the site awards.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Cancer Prevention Clinical Trials Network (CP-CTNet): CP-CTNet Sites (UG1 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.399.
• This funding opportunity was created on 2024-08-12.
• Applicants must submit their applications by 2024-10-31. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA CA 24 024

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